
Thermo Fisher Scientific TIMP1 Polyclonal Antibody
TIMP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Polyclonal 항체. Western blot, IHC, IP에 사용 가능하며, 인간 및 랫트 시료에 반응. 항원 친화 크로마토그래피로 정제된 Lyophilized 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (IHC) | 5–15 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant rat TIMP-1 (Cys24–Ala217) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609009 |
Product Specific Information
- In direct ELISAs, approximately 40% cross-reactivity with recombinant human (rh) TIMP-1 and recombinant mouse TIMP-1 is observed.
- Less than 1% cross-reactivity with rhTIMP-2, rhTIMP-3, and rhTIMP-4.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that forms one-to-one complexes with target metalloproteinases (e.g., collagenases), irreversibly inactivating them by binding to their catalytic zinc cofactor.
TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16.
It also functions as a growth factor regulating cell differentiation, migration, and apoptosis, and activates cellular signaling cascades via CD63 and ITGB1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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