Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Recombinant Rabbit Monoclonal Antibody (CD38/8114R)
CD38 단백질을 인식하는 재조합 토끼 단클론 항체로 인간 시료에 반응합니다. Western blot 및 면역조직화학(IHC)에 사용 가능하며, 높은 특이성과 재현성을 제공합니다. Protein A/G 정제, 액상 형태이며 4°C 보관. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Recombinant Rabbit Monoclonal Antibody (CD38/8114R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CD38/8114R |
| Immunogen | Recombinant fragment (around aa 200–300) of human CD38 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일 이름: 952-RBM16-P0_CD38_P28907-1_Rabbit.svg, 952-RBM16-P0_CD38_P28907-1_Rabbit_PDP.jpeg)
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