Thermo Fisher Scientific VIM Monoclonal Antibody (OTI3G4), TrueMAB
인간 Vimentin 단백질(aa 210-466)을 항원으로 제작된 Mouse IgG1 단일클론 항체로, Western blot에 최적화된 TrueMAB 형식입니다. 1 mg/mL 농도의 동결건조 형태로 제공되며, PBS buffer와 trehalose 포함, 연구용으로 사용됩니다.
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Applications
Tested Application
- Western Blot (WB)
Tested Dilution
- 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 210–466 of human VIM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Vimentin is a developmentally regulated intermediate filament protein found in cells of mesenchymal origin. It plays a role in intracellular protein transport between the nucleus and plasma membrane. Vimentin, along with desmin, is expressed during early cellular development and later replaced by tissue-specific intermediate filament proteins.
It is also involved in steroid synthesis regulation by serving as a storage network for cholesterol-containing lipid droplets. Phosphorylation of vimentin by protein kinase triggers filament breakdown and cytoskeletal changes, facilitating cholesterol transport to mitochondria and enhancing steroid synthesis.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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