Thermo Fisher Scientific MtTF1 Polyclonal Antibody
MtTF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능합니다. Protein A로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:300–1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent | |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 | |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MtTF1 (amino acids 155–246) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mitochondrial transcription factor A (TFAM) is a nuclear-encoded protein that translocates to mitochondria, where it plays a vital role in maintaining and expressing mitochondrial DNA (mtDNA). It regulates mtDNA replication and transcription, ensuring proper mitochondrial function. TFAM contains an LC3 interacting region (LIR) motif, enabling interaction with autophagy proteins like LC3, which supports the autolysosomal pathway to remove leaked mtDNA and reduce inflammation.
TFAM expression levels vary among tissues and influence mitochondrial performance. Elevated TFAM can repress mtDNA expression in skeletal muscle, contributing to oxidative phosphorylation (OXPHOS) deficiencies, while in cardiac tissue, increased mtDNA copy number helps maintain OXPHOS balance. TFAM is essential for mtDNA packaging, stability, and replication, and its dysregulation is linked to neurodegenerative and mitochondrial diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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