Thermo Fisher Scientific Human SPHK2, GST Tag Recombinant Protein

Thermo Fisher Scientific Human SPHK2, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Publications

• References

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material directly from original packaging.
• For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
• Do not store kinase diluted.
• Properly stored at -80°C, product guaranteed for 6 months from date of purchase.
• Protein Form: Full Length

Target Information

SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a key signaling molecule.
S1P interacts with G-protein coupled receptors to regulate diverse cellular processes such as differentiation, calcium mobilization, and apoptosis.
SPHK2 plays roles in cell motility, survival, migration, and cell-cell interaction, and is implicated in cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, and neuronal and bone cell regulation.
S1P levels are controlled by Sphk1 and Sphk2 activity.
Inhibitors of SPHKs are being studied as potential cancer therapeutics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.