Thermo Fisher Scientific CCR8 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1 µg/mL

Product Specifications

Product Specific Information

For Western Blot, this antibody has non-specific bands at 75 kDa.

Target Information

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into inflammatory sites. This receptor protein is preferentially expressed in the thymus. I-309, thymus activation-regulated cytokine (TARC), and macrophage inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies suggest its role in regulation of monocyte chemotaxis and thymic cell apoptosis. It may contribute to the proper positioning of activated T cells within antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located in the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen, thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.