Thermo Fisher Scientific NOL3 Monoclonal Antibody (6F5)
Thermo Fisher Scientific의 NOL3 Monoclonal Antibody (6F5)은 인간 ARC/NOL3 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체입니다. Western blot 및 ELISA에 적합하며, 비결합형 액상 형태로 제공됩니다. 세포 사멸 억제 관련 연구용으로 사용됩니다.
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Thermo Fisher Scientific NOL3 Monoclonal Antibody (6F5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6F5 |
| Immunogen | NOL3 (NP_003937.1, 1–208 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGNAQERPSE TIDRERKRLV ETLQADSGLL LDALLARGVL TGPEYEALDA LPDAERRVRR LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE AEPEPELEPE PDPEPEPDFE ERDESEDS
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms:
- Isoform 1: Involved in RNA splicing.
- Isoform 2: Functions as an apoptosis repressor blocking multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways by:
- Interacting with FAS and FADD to block DISC assembly upon FAS activation.
- Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, resulting in BAX inactivation and preventing mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical disorders.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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