Thermo Fisher Scientific GPR176 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
KCLIGTLVQL HHRYSRRNVV STGSGMAEAS LEPSIRSGSQ LLEMFHIGQQ QIFKPTEDEE ESEAKYIGSA DFQAKEIFST CLEGEQGPQF A

Ortholog sequence identity:

• Mouse: 84%
• Rat: 78%

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways.
G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and respond to a variety of signaling molecules, such as hormones and neurotransmitters.

GPR176 (G protein-coupled receptor 176), also known as HB-954, GPR or Gm1012, is a 515 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 1 family.
Expressed in brain and spleen, with trace expression in kidney, GPR176 functions as an orphan receptor thought to play a role in signaling events throughout the cell.
It contains four N-glycosylation sites, seven transmembrane domains, and a large C-terminal cytosolic domain, encoded by a gene mapping to human chromosome 15q14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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