Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (DA2)
HLA-DRB (MHC II) 단백질을 인식하는 Mouse IgG2b 단일클론 항체입니다. 인간 및 비인간 영장류 시료에 반응하며, WB, IHC, ICC, Flow 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태로 제공되며, 4°C에서 보관합니다.
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Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (DA2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DA2 |
| Immunogen | Activated human peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, part of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene and is expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.
These cells are crucial in capturing, processing, and presenting antigens to T cells for immune recognition.
HLA-DR beta plays a key role in presenting antigenic peptides to CD4⁺ T cells, thus activating adaptive immune responses.
The molecule consists of:
- Extracellular domain: Contains the peptide-binding groove interacting with antigenic peptides
- Transmembrane domain: Anchors the chain to the cell membrane
- Cytoplasmic tail: Involved in intracellular signaling
HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens through high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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