Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (DA2)

Thermo Fisher Scientific HLA-DRB (MHC II) Monoclonal Antibody (DA2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Does not react with Mouse

Target Information

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, part of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene and is expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells.
These cells are crucial in capturing, processing, and presenting antigens to T cells for immune recognition.
HLA-DR beta plays a key role in presenting antigenic peptides to CD4⁺ T cells, thus activating adaptive immune responses.
The molecule consists of:

• Extracellular domain: Contains the peptide-binding groove interacting with antigenic peptides
• Transmembrane domain: Anchors the chain to the cell membrane
• Cytoplasmic tail: Involved in intracellular signaling

HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens through high-performance liquid chromatography coupled with tandem mass spectrometry.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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