Thermo Fisher Scientific Human IL-22 Receptor alpha Synthetic Peptide
Human IL-22 Receptor alpha 합성 펩타이드로, IL-22 관련 연구에 활용 가능. PA5-19987 항체의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태이며 PBS 버퍼에 보관. 인간 특이 반응성을 가지며 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids at the amino terminus of human IL-22 Receptor.
PEP-0111 can be used as a blocking peptide with polyclonal antibody PA5-19987.
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling.
IL-22 and its receptor activate the JAK-STAT signaling pathway.
IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10.
A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently.
IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity.
LPS induces IL-22 expression, indicating the role of IL-22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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