Thermo Fisher Scientific RLTPR Polyclonal Antibody
인간 RLTPR 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50~1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 상태로 제공. T세포 보조자극 연구 및 세포 이동 관련 연구에 적합.
- 카탈로그번호
- PA559553
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RLTPR. Recombinant protein control fragment (Product #RP-98696). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646590 |
Product Specific Information
Immunogen sequence:
EVNELCQSVQ EHVELLGCGA GPQGEAAVRQ AEDAIQNANF SLSILPILYE AGSSPSHHWQ LGQKLEGLLR QVGEVCRQDI QDFTQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 92%
Target Information
RLTPR/CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein that binds CAPZA2 (capping protein muscle actin Z-line alpha 2) with high affinity and decreases CAPZA2 affinity for actin barbed ends.
RLTPR/CARMIL2 increases actin filament elongation rate in the presence of CAPZA2 but cannot nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation.
RLTPR/CARMIL2 is crucial for T cell costimulation via CD28, independent of its actin-uncapping function. Lack of functional RLTPR/CARMIL2 impedes differentiation toward Th1 and Th17 fates in both human and murine CD4+ T cells, leading to combined immunodeficiency. Expression is also detected in B cells, though not involved in BCR-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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