Thermo Fisher Scientific Human AIPL1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human Aipl1.
PEP-0744 can be used as a blocking peptide with polyclonal antibody PA5-20624.

Target Information

Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors.
Aipl1 is a tetratricopeptide repeat protein highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor.
Aipl1 functions as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70, and also associates with the cell cycle regulator NUB1.
It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in normal photoreceptor maturation. Mutations that lead to LCA compromise these interactions with Hsp chaperones.
At least three isoforms of Aipl1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.