Thermo Fisher Scientific CSN7b Polyclonal Antibody
Rabbit polyclonal antibody against human CSN7b protein. Validated for Western blot with high specificity. Predicted cross-reactivity with mouse and bovine. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:25,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 and the C-terminus (residue 264) of human constitutive photomorphogenic homolog subunit 7B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Bovine
Target Information
Component of the COP9 signalosome complex (CSN), which regulates various cellular and developmental processes.
The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway, mediating deneddylation of cullin subunits of SCF-type E3 ligase complexes, thereby reducing Ubl ligase activity of complexes such as SCF, CSA, or DDB2.
It also participates in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1, and IRF8/ICSBP, possibly through association with CK2 and PKD kinases.
CSN-dependent phosphorylation of TP53 and JUN promotes or protects degradation by the Ubl system, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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