Thermo Fisher Scientific FOXO1A Monoclonal Antibody (3G1)
FOXO1A 단백질을 인식하는 Thermo Fisher Scientific의 3G1 클론 단일클론 항체로, WB, IHC, ICC/IF에 적용 가능. Rabbit IgG 기반, 비결합형 액상 형태이며 -20°C 보관. 세포 성장, 대사 조절 및 자가포식 관련 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FOXO1A Monoclonal Antibody (3G1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G1 |
| Immunogen | Recombinant human FOXO1A protein, around 300–400 aa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a transcription factor belonging to the forkhead homeotic gene family. It functions as a coactivator or corepressor of nuclear receptor activity through the LXXLL motif in its C-terminal region. Association with PAX3 is implicated in alveolar rhabdomyosarcoma. FOXO1 is linked to anti-tumor activity, autophagy, and myogenic differentiation. It is a key target of insulin signaling, regulating metabolic homeostasis under oxidative stress. FOXO1 binds to insulin response elements (IRE) and Daf-16 family binding elements (DBE), and regulates redox balance, osteoblast numbers, and bone mass. It orchestrates skeletal endocrine function, suppresses RUNX2 activity, and promotes gluconeogenesis in hepatocytes by activating genes such as IGFBP1, G6PC, and PCK1. FOXO1 acts downstream of CDK1, PKB/AKT1, and STK4/MST1 to regulate cell death.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.