Thermo Fisher Scientific DLG4 Polyclonal Antibody, MaxPab

Thermo Fisher Scientific DLG4 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)
  Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSQRPRAPRS ALWLLAPPLL RWAPPLLTVL HSDLFQALLD ILDYYEASLS ESQKYRYQDE DTPPLEHSPA HLPNQANSPP VIVNTDTLEA PGYELQVNGT EGEMEYEEIT LERGNSGLGF SIAGGTDNPH IGDDPSIFIT KIIPGGAAAQ DGRLRVNDSI LFVNEVDVRE VTHSAAVEAL KEAGSIVRLY VMRRKPPAEK VMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG GAAHKDGRLQ IGDKILAVNS VGLEDVMHED AVAALKNTYD VVYLKVAKPS NAYLSDSYAP PDITTSYSQH LDNEISHSSY LGTDYPTAMT PTSPRRYSPV AKDLLGEEDI PREPRRIVIH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA DLSGELRKGD QILSVNGVDL RNASHEQAAI ALKNAGQTVT IIAQYKPEEY SRFEAKIHDL REQLMNSSLG SGTASLRSNP KRGFYIRALF DYDKTKDCGF LSQALSFRFG DVLHVIDASD EEWWQARRVH SDSETDDIGF IPSKRRVERR EWSRLKAKDW GSSSGSQGRE DSVLSYETVT QMEVHYARPI IILGPTKDRA NDDLLSEFPD KFGSCVPHTT RPKREYEIDG RDYHFVSSRE KMEKDIQAHK FIEAGQYNSH LYGTSVQSVR EVAEQGKHCI LDVSANAVRR LQAAHLHPIA IFIRPRSLEN VLEINKRITE EQARKAFDRA TKLEQEFTEC FSAIVEGDSF EEIYHKVKRV IEDLSGPYIW VPARERL

Target Information

Post Synaptic Density 95 kDa (PSD-95), also known as synapse-associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum.
Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain.
PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
There are two principal modes of interaction between PSD-95 and other proteins:

1. NMDA receptors and Shaker-type potassium channels share a C-terminal sequence homology with a threonine/serine-X-valine-COOH (T/SXV) motif.
2. Other neuronal proteins that share this motif (β1 adrenergic receptor, some serotonin receptors, sodium channel subunits, and additional potassium channel subunits) may interact with PSD-95 via its PDZ domains.

Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but has its own PDZ domain, can associate with PSD-95 through a pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.