Thermo Fisher Scientific CD163 Monoclonal Antibody (8G1)

Thermo Fisher Scientific CD163 Monoclonal Antibody (8G1)

Applications and Tested Dilution

Product Specifications

Target Information

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin–haptoglobin complex, protecting tissues from oxidative damage and playing a role in iron recycling via endocytosis and heme breakdown.
CD163 is expressed on the surface of human monocytes and macrophages, predominantly in the late phase of inflammation. It is found on all circulating monocytes and most tissue macrophages except those in mantle zones, germinal centers, interdigitating reticulum cells, and Langerhans cells.
Expression is upregulated by IL-10, IL-6, and dexamethasone, while LPS and PMA induce shedding of CD163 from the cell surface. CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, with higher affinity for multimeric haptoglobin complexes (HP1F phenotype). It also triggers intracellular signaling cascades involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL-6 and CSF1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.