Thermo Fisher Scientific FAS Monoclonal Antibody (2G3)
인간 FAS 단백질을 인식하는 Mouse IgG2a 형 단클론 항체로, Western blot, ELISA, in situ PLA에 적합합니다. PBS 기반 액상 형태이며 보존제가 없습니다. 세포 사멸 경로 연구 및 FAS 관련 신호전달 분석에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 3 ng/mL |
| in situ PLA | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G3 |
| Immunogen | FAS (NP_000034, 20 a.a. approximately 119 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SKSVNAQVTD INSKGLELRK TVTTVETQNL EGLHHDGQFC HKPCPPGERK ARDCTVNGDE PDCVPCQEGK EYTDKAHFSS KCRRCRLCDE GHGLEVEINC
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble form (~26 kDa). Stimulation of FAS leads to aggregation of intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases, triggering apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and participate in proliferative signaling in fibroblasts and T cells. Multiple alternatively spliced transcript variants exist, with some isoforms lacking the transmembrane domain, negatively regulating apoptosis. The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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