Thermo Fisher Scientific BTLA Chimeric Recombinant Armenian Hamster Monoclonal Antibody (HMBT-6B2)
BTLA 단백질을 인식하는 아르메니아 햄스터 유래 키메라형 재조합 단클론 항체. T세포 활성 억제 및 B세포 증식 조절 연구에 사용. 다양한 어세이(WB, Flow, IP 등)에 적용 가능. 비결합형, Protein A 정제, HEK293 발현.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Armenian hamster / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HMBT-6B2 |
| Immunogen | This antibody was raised by immunising Armenian hamsters with mouse BTLA:Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody is specific for B and T lymphocyte attenuator (BTLA), which functions as a negative regulator of T cell activation and proliferation, and attenuates B cell proliferation upon associating with its known ligand, herpes virus entry mediator (HVEM).
Target Information
BTLA (B and T-lymphocyte attenuator) is a member of the co-inhibitory receptors of the CD28 superfamily. It acts as a lymphocyte inhibitory receptor that regulates immune responses by inhibiting lymphocyte activation. BTLA is constitutively expressed on most CD4+ and CD8+ T cells, with expression decreasing upon activation. It remains expressed on Th1 cells but not Th2 cells. BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM, forming an important pathway in lymphocyte activation and immune homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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