Thermo Fisher Scientific ZFYVE19 Polyclonal Antibody
Thermo Fisher Scientific의 ZFYVE19 폴리클로날 항체는 인간 ZFYVE19 단백질을 인식하며, Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었고, 액상 형태로 제공됩니다. 세포질 분열 조절 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ZFYVE19. Recombinant protein control fragment (Product #RP-104747) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664422 |
Product Specific Information
Immunogen sequence:
SGCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS Q
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 85%
Target Information
ZFYVE19 is a key regulator of the abscission step in cytokinesis and part of the cytokinesis checkpoint. It prevents premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, it retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until checkpoint signaling is terminated. Deactivation of AURKB leads to dephosphorylation of CHMP4C, its dissociation from ZFYVE19/ANCHR and VPS4, and subsequent abscission.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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