Thermo Fisher Scientific MAVS Monoclonal Antibody (OTI9C4), TrueMAB
MAVS 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western Blot 및 IHC(P)에서 사용 가능. 인간 MAVS(aa 1-247) 재조합 단백질을 면역원으로 제작. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보존. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–247 of human MAVS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger immune responses.
MAVS is a mitochondrial membrane protein critical for IFN-β signaling, recruiting IRF-3 to RIG-I and activating NF-κB. It interacts with innate immune components such as TRIF, TRAF2, TRAF6, and kinases IKK-α, IKK-β, and IKK-ι.
Cleavage of MAVS by Hepatitis C virus protease enables viral immune evasion. Multiple isoforms of MAVS are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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