Thermo Fisher Scientific NSFL1C Polyclonal Antibody
Rabbit polyclonal antibody targeting human NSFL1C (p47) for WB and IP applications. Recognizes conserved regions across species. Supplied as 1 mg/mL liquid form, stored at 4°C. For research use only.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 to 75 of human NSFL1 (p97) Cofactor (p47) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan
Target Information
p47, also known as NSFL1C, UBX1, UBXD10, or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the Golgi apparatus (specifically to Golgi stacks). It contains one SEP domain and one UBX domain.
Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP. It is required for the fragmentation of Golgi stacks during mitosis and for subsequent reassembly after mitosis.
p47 is phosphorylated during mitosis, which inhibits p47-Golgi interaction and is required for proper Golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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