Thermo Fisher Scientific HDAC4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human HDAC4. Validated for WB and IP applications. Recognizes residues 550–600 of HDAC4. Supplied as a liquid, unconjugated form at 1 mg/mL. Recommended storage at 4°C and shipped on wet ice.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human Histone Deacetylase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation provides a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. HDAC4 acts via the formation of large multiprotein complexes and is involved in muscle maturation through interactions with myocyte enhancer factors such as MEF2A, MEF2C, and MEF2D. It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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