Thermo Fisher Scientific LMNA Monoclonal Antibody (OTI3F6), TrueMAB
LMNA 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot에 적합합니다. 인간 시료에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. PBS/BSA/glycerol buffer에 보관되며, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F6 |
| Immunogen | Full length human recombinant protein of human LMNA produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins comprise three proteins arising from the same gene by alternative splicing — lamin A, lamin C, and lamin Adel 10 — while B-type lamins include two proteins from distinct genes, lamin B1 and lamin B2.
Mutations in A-type lamins are associated with rare dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are linked to cell differentiation and chromatin interaction, suggesting a role in differential gene expression regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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