Thermo Fisher Scientific Phospho-DRP1 (Tyr504) Polyclonal Antibody
Phospho-DRP1 (Tyr504) 항체로, 인산화된 CRMP1의 Tyr504 부위를 특이적으로 검출합니다. Western blot과 IHC(Paraffin)에 적합하며, Rabbit Polyclonal IgG 형태입니다. 인간, 마우스, 랫트 반응성이 있으며, PBS/glycerol buffer에 보존됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CRMP1 (Accession Q14194), corresponding to amino acid residues around phosphorylated Tyr504. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817382 |
Product Specific Information
This antibody detects endogenous levels of CRMP-1 only when phosphorylated at Tyr504.
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and olfactory system suggests involvement in adult brain plasticity.
CRMP-1, initially identified as a dihydro-pyrimidinase expressed exclusively in brain, is involved in neurotrophin (NT) 3-induced neurite formation and outgrowth. Its localization shifts from axonal to somatodendritic as neurons mature, indicating roles in both neuronal differentiation and survival or death of newly generated neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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