Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI4B1), TrueMAB
ABCC5 단백질을 인식하는 Mouse Monoclonal Antibody로 Western Blot에 적합. Human 시료에서 반응하며, 고순도의 Affinity chromatography 정제 제품. PBS/BSA/glycerol buffer에 보존되어 안정적이며 연구용으로 사용 가능.
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Applications
- Western Blot (WB): 1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B1 |
| Immunogen | Full length human recombinant protein of human ABCC5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
ABCC5 belongs to the MRP subfamily involved in multidrug resistance and mediates cellular export of cyclic nucleotides, contributing to their degradation and elimination.
This protein confers resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in drug resistance in acute lymphoblastic leukemia and HIV-infected patients.
Alternative splicing has been observed, though the complete sequence and translation initiation site are unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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