Thermo Fisher Scientific CD127 Recombinant Rabbit Monoclonal Antibody (JE37-10)
CD127 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합합니다. 인간 시료에 반응하며, 단백질 A로 정제된 액상 형태입니다. 세포막 및 분비 단백질 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:500–1:1000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE37-10 |
| Immunogen | Recombinant protein within Human CD127 aa 340–439/459 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092881 |
Product Specific Information
- Positive control: K562 cell lysates, SiHa, human tonsil tissue, K-562
- Predicted band size: 52 kDa
- Subcellular Location: Cell membrane; Secreted
Target Information
CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The cellular response to CD127 depends on the presence of the interleukin-7 receptor (IL7R), which functions as an alpha/gamma chain heterodimer.
The gamma(c) chain, also shared with the interleukin-2 receptor, primarily activates signal transduction by the IL7R complex, while the alpha chain determines specific signaling through association with cytoplasmic molecules.
CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells.
Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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