Thermo Fisher Scientific HP1 alpha Polyclonal Antibody, Biotin
HP1 alpha 단백질을 인식하는 Biotin 결합 폴리클로날 항체. Western blot에 적합하며, 인간 시료에 반응. 고순도(암모늄 황산염 침전) 정제 및 안정한 TBS 버퍼 제형. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-NKRKSNFSNSADDIK (aa 88–102) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932839 |
Product Specific Information
This antibody is tested in Peptide ELISA with an antibody detection limit dilution of 1:128,000.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian histone methyltransferases that methylate histone H3 on lysine-9 create a binding site for HP1 proteins, which function as heterochromatic adaptor molecules involved in gene silencing and chromatin structure organization. High-affinity recognition of methylated histone H3 by HP1 requires a functional chromodomain, serving as a specific motif for the methyl epitope on lysine-9. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-mutant mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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