Thermo Fisher Scientific HP1 alpha Polyclonal Antibody, Biotin

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.3 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA with an antibody detection limit dilution of 1:128,000.

Target Information

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian histone methyltransferases that methylate histone H3 on lysine-9 create a binding site for HP1 proteins, which function as heterochromatic adaptor molecules involved in gene silencing and chromatin structure organization. High-affinity recognition of methylated histone H3 by HP1 requires a functional chromodomain, serving as a specific motif for the methyl epitope on lysine-9. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-mutant mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.