Thermo Fisher Scientific TEM7 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Immunohistochemistry (Paraffin) (IHC (P))
1:20-1:50
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TEM7. Recombinant protein control fragment (Product #RP-90375). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
TEM7,
uniProtId:
Q8IUK5-1,
ncbiNodeId:
9606,
antigenRange:
308-425,
antigenLength:
500,
antigenImageFileName:
PA5-110778_TEM7_Q8IUK5-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-110778_TEM7_Q8IUK5-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856189
Product Specific Information
Immunogen sequence: RSCDACMSSD LTFNCSWCHV LQRCSSGFDR YRQEWMDYGC AQEAEGRMCE DFQDEDHDSA SPDTSFSPYD GDLTTTSSSL FIDSLTTEDD TKLNPYAGGD GLQNNLSPKT KGTPVHLG
Target Information
Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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