Thermo Fisher Scientific c-Fos Polyclonal Antibody
Thermo Fisher Scientific의 c-Fos Polyclonal Antibody는 Western blot과 Immunohistochemistry에 적합한 항체입니다. 인간 c-Fos 단백질 유래 합성 펩타이드를 면역원으로 사용하였으며, 비결합형 동결건조 형태로 제공됩니다. 연구용으로 세포 신호전달 및 발현 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human c-Fos protein conjugated to blue carrier protein has been used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978437 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 500 µL of distilled water.
- Centrifuge to remove insoluble material.
Target Information
FBJ murine osteosarcoma viral oncogene homolog, commonly known as Cellular proto-oncogene Fos (c-Fos), belongs to the Fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14.
c-Fos heterodimerizes with c-Jun to form the Activator Protein-1 (AP-1) transcription factor, which regulates transcription of genes involved in cellular signal transduction, proliferation, and differentiation.
It is phosphorylated by various stimuli including growth factors and insulin at multiple sites. The upstream kinase ERK MAPK phosphorylates c-Fos at Threonine 232, regulating its nuclear localization and transcriptional activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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