Thermo Fisher Scientific FAM38A Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Target Information

Piezo1 (FAM38A) is a pore-forming subunit of a mechanosensitive non-specific cation channel that generates currents characterized by a linear current-voltage relationship sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.

Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, Piezo1 contributes to the detection of intraluminal pressure changes and urine flow sensing. It acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation, playing a key role in blood vessel formation and vascular structure during development and adult physiology.

Defects in the PIEZO1 gene are associated with dehydrated hereditary stomatocytosis, pseudohyperkalemia, perinatal edema, and lymphedema.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.