Thermo Fisher Scientific FAM38A Polyclonal Antibody, Biotin
FAM38A(Piezo1) 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체입니다. Western blot, ELISA, IP에 사용 가능하며, 인간 시료에 반응합니다. 고순도 친화 크로마토그래피 정제 제품으로 -20°C에서 보관합니다.
- 카탈로그번호
- FAM38A-BIOTIN
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken between TMD14 and TMD15 on human FAM38A protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Piezo1 (FAM38A) is a pore-forming subunit of a mechanosensitive non-specific cation channel that generates currents characterized by a linear current-voltage relationship sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.
Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, Piezo1 contributes to the detection of intraluminal pressure changes and urine flow sensing. It acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation, playing a key role in blood vessel formation and vascular structure during development and adult physiology.
Defects in the PIEZO1 gene are associated with dehydrated hereditary stomatocytosis, pseudohyperkalemia, perinatal edema, and lymphedema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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