Thermo Fisher Scientific CaMKIV Polyclonal Antibody
Mouse CaMKIV 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of mouse CaMKIV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690891 |
Product Specific Information
This target displays homology in the following species:
- Mouse: 100%
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells. The nuclear localization of this protein supports its role in calcium-dependent gene expression. CaMKIV is abundant in testis, T-cells, and neurons, and is also found in other tissues to varying degrees.
In neurons, CaMKIV contributes to synaptic plasticity through gene regulatory effects. In T-cells, it is crucial for calcium signaling, influencing transcriptional regulators such as NFAT. CaMKIV and calspermin are encoded by the CaMKIV gene. In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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