Thermo Fisher Scientific TSLP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is Jurkat cell lysate.
PA5-20319 can be used with blocking peptide PEP-0439.

Target Information

TSLP is a 159 amino acid four-helix bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain.
It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c(+) dendritic cells, naive CD4(+) and CD8(+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation.
TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4(+) T cell homeostasis.
It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis.
It is expressed in heart, liver, and prostate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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