Thermo Fisher Scientific Myeloid-Associated Differentiation Marker (MYADM) Monoclonal Antibody (MYADM, 972)
MYADM 단백질을 표적하는 Mouse IgG1 단일클론 항체로, 인간 및 비인간 영장류 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 혈액세포 분화 연구 및 진단·예후 마커 연구용에 적합합니다.
- 카탈로그번호
- 91663-MSM2-P0
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MYADM, 972 |
| Immunogen | Recombinant human MYADM protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes.
Target Information
MYADM, belonging to the MAL family, is a 322-amino acid protein having seven hydrophobic transmembrane domains, potential phosphorylation sites, and sequence homology with the T-cell differentiation protein MAL and plasmolipin.
It shares 75.8% sequence identity with mouse in the transmembrane regions and is associated with differentiation of hematopoietic or acute promyelocytic leukemia cells.
Expression is up-regulated in NB4 cells induced by all-trans retinoic acid, while down-regulation inhibits colony formation of bone marrow cells.
MYADM serves as a potential marker for hematopoietic differentiation and may be used for diagnostic, prognostic, or therapeutic studies.
It is expressed widely in brain and pancreatic islet cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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