Thermo Fisher Scientific Myeloid-Associated Differentiation Marker (MYADM) Monoclonal Antibody (MYADM, 972)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes.

Target Information

MYADM, belonging to the MAL family, is a 322-amino acid protein having seven hydrophobic transmembrane domains, potential phosphorylation sites, and sequence homology with the T-cell differentiation protein MAL and plasmolipin.
It shares 75.8% sequence identity with mouse in the transmembrane regions and is associated with differentiation of hematopoietic or acute promyelocytic leukemia cells.
Expression is up-regulated in NB4 cells induced by all-trans retinoic acid, while down-regulation inhibits colony formation of bone marrow cells.
MYADM serves as a potential marker for hematopoietic differentiation and may be used for diagnostic, prognostic, or therapeutic studies.
It is expressed widely in brain and pancreatic islet cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.