Thermo Fisher Scientific Myc Monoclonal Antibody (9E10), Agarose, TrueMAB

Applications

Tested Dilution

Publications

Immunoprecipitation (IP)

Assay-Dependent

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

9E10

Immunogen

Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 408-432 of human c-Myc

Conjugate

Agarose Agarose Agarose

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Peptide sequence is AEEQKLISEEDLLRKRREQLKHKLE

Target Information

Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.