Thermo Fisher Scientific DR6 Monoclonal Antibody (03)
Human TNFRSF21/DR6 단백질을 인식하는 Mouse IgG1 단일클론 항체. ELISA에서 1:1,000–1:2,000 희석으로 사용 가능. 보존제가 없는 액상 형태로 제공되며, Protein A로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 03 |
| Immunogen | Recombinant Human TNFRSF21/DR6 Protein (Met1–Leu350) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786906 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human TNFRSF21/DR6.
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas.
Several novel death receptors including DR3, DR4, and DR5 were recently identified.
A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6.
Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD.
Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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