Thermo Fisher Scientific EGLN2 Monoclonal Antibody (OTI5E11), TrueMAB
인간 EGLN2 단백질을 인식하는 mouse IgG1 단일클론 항체. Western blot에 최적화되어 있으며, 고순도 친화 크로마토그래피로 정제됨. PBS/BSA/glycerol 버퍼에 보존되어 안정적이며 연구용으로 적합.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E11 |
| Immunogen | Full length human recombinant protein of human EGLN2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2, and HIF PHD3 (known as PHD1, PHD2, and PHD3 in rodents, respectively) hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator essential in oxygen homeostasis.
The prolyl hydroxylases catalyze posttranslational formation of 4-hydroxyproline in HIF-alpha proteins.
HIF PHD1, widely expressed with highest levels in testis, acts as a cellular oxygen sensor and regulates cell growth. It localizes to nucleus or cytoplasm and is detected in hormone-responsive tissues such as mammary, ovarian, and prostate epithelium.
HIF PHD1 is encoded by EGLN2, located on chromosome 19q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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