Thermo Fisher Scientific ACVR2A Monoclonal Antibody (C11)

Applications

Western Blot (WB)

• Tested Dilution: 0.01–2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–20 µg/mL

Product Specifications

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A participates in the activin and myostatin signaling pathways.
Aliases: ACVR2, ACTRII.

These receptors are transmembrane proteins composed of:

• A ligand-binding extracellular domain with a cysteine-rich region
• A transmembrane domain
• A cytoplasmic domain with serine/threonine kinase specificity

Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.