Thermo Fisher Scientific ACVR2A Monoclonal Antibody (C11)
ACVR2A 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(C11)입니다. Western blot과 IHC(P)에서 사용 가능하며, 인간 시료에 반응합니다. 고순도 Protein A/G 정제, 액상 형태, -20°C 보관.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C11 |
| Immunogen | Recombinant protein Activin A Receptor Type II A (amino acids 20–135) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899024 |
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A participates in the activin and myostatin signaling pathways.
Aliases: ACVR2, ACTRII.
These receptors are transmembrane proteins composed of:
- A ligand-binding extracellular domain with a cysteine-rich region
- A transmembrane domain
- A cytoplasmic domain with serine/threonine kinase specificity
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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