Thermo Fisher Scientific SCN2B Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

Scn2b is a member of voltage-gated sodium channels (NaV) responsible for action potential initiation and propagation in excitable cells such as nerve, muscle, and neuroendocrine cells. It is also expressed at low levels in non-excitable cells, where its physiological role remains unclear.

Scn2b plays a crucial role in the assembly, expression, and functional modulation of the heterotrimeric sodium channel complex. The beta-2 subunit increases plasma membrane surface area and folding into microvilli. It interacts with Tenascin R (TNR) and is involved in clustering and regulation of sodium channels at nodes of Ranvier.

The SCN2B gene encodes the beta-2 subunit of the type II voltage-gated sodium channel, contributing to cell-cell adhesion and migration. Defects in SCN2B may cause Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. Diseases associated with SCN2B include Atrial Fibrillation, Familial 14, and Scn2b-Related Familial Atrial Fibrillation.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.