Thermo Fisher Scientific RIMS2 Monoclonal Antibody (3C12)
RIMS2 단백질을 인식하는 Mouse IgM 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 시료에 반응하며, 비표지 액상 형태로 제공됩니다. 신경전달 관련 단백질 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C12 |
| Immunogen | RIMS2 (NP_055492, 181 a.a. approximately 260 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS PPTPRRSPLP IDRPDLRRTD
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins essential for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While deletion of either gene alone is not lethal in mice, deletion of both results in postnatal mortality due to defects in neurotransmitter release. Synapses lacking RIM proteins can still release neurotransmitters but fail to respond to normal Ca²⁺ triggers. Like Rim1, Rim2 functions as an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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