Thermo Fisher Scientific Human Factor X Native Protein

Applications

• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-43072 contains native human Factor X protein purified from blood/plasma.
This product may be used as a positive control in various immunological assays.
The product is derived from human blood/plasma. Although the starting material was tested and found negative or nonreactive for anti-HIV-1/2, HIV-1 antigens, HBsAg, STS, anti-HCV, anti-HBcore, and anti-HTLV I & II, extreme caution should be exercised when handling this material due to the inherent margin of error in all tests.
For in vitro research use only. Not intended for clinical or diagnostic use.

Target Information

F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by excision of the tripeptide RKR.
Two chains of the factor are linked by one or more disulfide bonds:

• The light chain contains two EGF-like domains.
• The heavy chain contains the catalytic domain, structurally homologous to other hemostatic serine proteases.

The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or by factor VIIa (extrinsic pathway).
Activated Factor X converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations in this gene cause factor X deficiency, a hemorrhagic disorder of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.