Thermo Fisher Scientific SDE2 Polyclonal Antibody

Applications

• Western Blot (WB): Tested at 1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: VSAEISENRK RQWPTKSQTD RGASAGKRRC FWLGMEGLET AEGSNSESSD
• Sequence homology: Human: 100%

Target Information

Involved in both DNA replication and cell cycle control (PubMed:27906959).
Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter, thereby inhibiting translesion DNA synthesis.
Binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain.
The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage-dependent manner (PubMed:27906959).
Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light-induced replication stress.
Complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959).
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.