Thermo Fisher Scientific MRCK alpha Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CDC42BPA. Recombinant protein control fragment (Product #RP-107808). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MRCK alpha,uniProtId:Q5VT25-1,ncbiNodeId:9606,antigenRange:746-806,antigenLength:1732,antigenImageFileName:PA5-84863_MRCK_alpha_Q5VT25-1_Rabbit.svg,antigenImageFileNamePDP:PA5-84863_MRCK_alpha_Q5VT25-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792012

Product Specific Information

Immunogen sequence: TRRESQSERE EFESEFKQQY EREKVLLTEE NKKLTSELDK LTTLYENLSI HNQQLEEEVK D

Target Information

CDC42BPA (MRCKA) is a serine/threonine kinase which functions in actin cytoskeleton assembly and organization. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.