Thermo Fisher Scientific HDAC3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Positive test controls: HeLa, K-562, NIH/3T3, Mouse brain, Mouse spleen, Rat kidney
• Subcellular localization: Cytoplasm, Nucleus, Cytosol

Immunogen sequence:
FEYFAPDFTL HPDVSTRIEN QNSRQYLDQI RQTIFENLKM LNHAPSVQIH DVPADLLTYD RTDEADAEER GPEENYSRPE APNEFYDGDH DNDKESDVEI

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
It may participate in transcription regulation through binding with the zinc-finger transcription factor YY1.
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.
This gene is regarded as a potential tumor suppressor gene.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.