Thermo Fisher Scientific HDAC3 Polyclonal Antibody
HDAC3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합. Human, Mouse, Rat 시료에서 반응하며, Affinity Chromatography로 정제됨. PBS/glycerol 용액 형태로 -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 329–428 of human HDAC3 (NP_0038742) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.24 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914026 |
Product Specific Information
- Positive test controls: HeLa, K-562, NIH/3T3, Mouse brain, Mouse spleen, Rat kidney
- Subcellular localization: Cytoplasm, Nucleus, Cytosol
Immunogen sequence:
FEYFAPDFTL HPDVSTRIEN QNSRQYLDQI RQTIFENLKM LNHAPSVQIH DVPADLLTYD RTDEADAEER GPEENYSRPE APNEFYDGDH DNDKESDVEI
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
It may participate in transcription regulation through binding with the zinc-finger transcription factor YY1.
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.
This gene is regarded as a potential tumor suppressor gene.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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