Thermo Fisher Scientific NKCC2 Polyclonal Antibody
Human NKCC2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로 신장 Na-K-Cl 수송체 분석에 적합.
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- PA553263
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC12A1. Recombinant protein control fragment (Product #RP-91245) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647346 |
Product Specific Information
Immunogen sequence:
MSLNNSSNVF LDSVPSNTNR FQVSVINENH ESSAAADDNT DPPHYEETSF GDEAQKRLRI SFRPGNQECY DNFLQSGETA KTDASFHAYD SHTNTYYLQT FGHNTMDAVP KIEYYRNTGS I
Highest antigen sequence identity to the following orthologs:
- Mouse: 76%
- Rat: 80%
Target Information
The sodium-potassium-chloride cotransporter isoform 2 (NKCC2) is kidney-specific and located on the apical membrane of the thick ascending limb of Henle’s loop and the macula densa. It mediates NaCl resorption (1Na:1K:2Cl stoichiometry) and is sensitive to diuretics such as furosemide and bumetanide. Mutations in this gene may lead to Bartter-like syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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