Thermo Fisher Scientific Human ITGA4 Synthetic Peptide

Thermo Fisher Scientific Human ITGA4 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the center of human integrin alpha 4.
PEP-0720 can be used as a blocking peptide with polyclonal antibody PA5-20600.

Target Information

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7 chain.
It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 are located on the alpha4 chain. These ligands include Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7.
Recent studies have shown that the HIV-1 envelope can mimic Madcam by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.