Thermo Fisher Scientific Neuropeptide Q2/NPQ2 Polyclonal Antibody

Thermo Fisher Scientific Neuropeptide Q2/NPQ2 Polyclonal Antibody

Applications

• Immunohistochemistry (IHC)
  Tested Dilution: 1:100–1:600

Product Specifications

Target Information

Spexin hormone acts as a central modulator of cardiovascular and renal function and nociception. It also plays a role in energy metabolism and storage and inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release.

Spexin is cleaved into two chains — Spexin-1 and Spexin-2.

• Spexin-1: Ligand for galanin receptors GALR2 and GALR3. Induces increased arterial blood pressure, decreased heart rate and renal excretion, and delayed natriuresis. Also induces contraction of muscarinic-like stomach smooth muscles, reduces food consumption and body weight, and inhibits long-chain fatty acid uptake into adipocytes.
• Spexin-2: Decreases heart rate without changing arterial pressure and increases urine flow rate.

Both Spexin-1 and Spexin-2 induce antinociceptive activity when administered intraventricularly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.