Thermo Fisher Scientific NPM1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NPM1 for WB and IP applications. Recognizes residues 100–150 of NPM1. Supplied as liquid at 0.20 mg/mL, stored at 4°C. Predicted cross-reactivity with rat and bovine. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 and 150 of human nucleophosmin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly and transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and p53 regulation.
NPM1 shuttles between nucleus, cytoplasm, and nucleolus, chaperoning core histones and preventing protein aggregation. It aids enzyme protection during thermal denaturation and assists renaturation of denatured proteins.
NPM1 is associated with centrosomes and acts as a substrate for CDK2/cyclin E during centrosome duplication. It is linked to tumor-associated translocations forming fusion proteins such as NPM-ALK, NPM-RAR, and NPM-MLF1, serving as an interface for oligomerization and oncogenic conversion.
Additionally, NPM1 sequesters tumor suppressor RF in the nucleolus to prevent degradation. Dysfunction of NPM1 is associated with acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항원 구조 이미지 포함)
- A302-402A-M_NPM1_P06748-1_Rabbit.svg
- A302-402A-M_NPM1_P06748-1_Rabbit_PDP.jpeg
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