Thermo Fisher Scientific Pc2 Polyclonal Antibody
Rabbit polyclonal antibody against human Pc2 (CBX4) for IHC and IHC-P applications. Recognizes human and mouse, predicted cross-reactivity with multiple species. Antigen affinity purified, supplied in liquid form, stored at 4°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of human polycomb 2 (chromobox homolog 4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Rabbit, Guinea pig, Pig, Panda, Monkey, Gorilla, Chimpanzee, Gray short-tailed opossum, and Naked mole rat
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins essential for embryonic and adult stem cell self-renewal and maintenance.
At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation.
Depletion of CBX4 results in decreased cellular resistance to ionizing radiation and is directly involved in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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