Thermo Fisher Scientific PCK1 Polyclonal Antibody

Applications

Product Specifications

Target Information

Phosphoenolpyruvate Carboxykinase 1 (PCK1) is a main control point for the regulation of gluconeogenesis. During gluconeogenesis, PCK1 acts as the rate-limiting enzyme. It regulates the formation and maintenance of memory CH8(+) T-cells via gluconeogenesis and controls metabolic intermediates in the citric acid cycle by regulating cataplerosis and anaplerosis.
When glucose levels are high, PCK1 catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP). When low, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate.
When phosphorylated at Ser-90 by AKT1, PCK1 acts as a protein kinase by reducing binding affinity to oxaloacetate and promoting an atypical serine protein kinase activity using GTP as the donor. This activity regulates lipogenesis by disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins and transcription of lipogenesis-related genes.
An important paralog of this gene is PCK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.