Thermo Fisher Scientific SIGLEC7 Monoclonal Antibody (OTI1A11), TrueMAB

Applications

• Western Blot (WB): 1:4,000 dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

SIGLEC7 is a putative adhesion molecule that mediates sialic acid-dependent binding to cells, preferentially binding to α-2,3 and α-2,6-linked sialic acids. It also interacts with disialogangliosides. The sialic acid recognition site may be masked by cis interactions on the same cell surface.
In immune response, SIGLEC7 acts as an inhibitory receptor through ligand-induced tyrosine phosphorylation, recruiting cytoplasmic phosphatases that block signal transduction. It mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis by inhibiting differentiation of CD34+ precursors toward myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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